Production of Human Papillomavirus Type-16 L1 VLP in Pichia pastoris
نویسندگان
چکیده
منابع مشابه
Human Papillomavirus Type16- L1 VLP Production in Insect Cells
Objective(s): Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...
متن کاملhuman papillomavirus type16- l1 vlp production in insect cells
objective(s): infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. recombinant dna technology allows expression of the l1 major capsid protein of hpv in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (vlp). vlps are non-infectious, highly immunogenic and can elicit neutralizing a...
متن کاملHuman Papillomavirus Type16- L1 VLP Production in Insect Cells
OBJECTIVE(S) Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing ant...
متن کاملOptimum conditions for production and purification of human papillomavirus type 16 L1 protein from Saccharomyces cerevisiae.
Several prophylactic human papillomavirus (HPV) vaccines have been developed based on virus-like particles (VLPs) made from viral L1 proteins. A substantial number of VLPs is necessary for biochemical characterization and diagnostic test development. To establish the optimum conditions for production and purification of HPV L1 in the yeast expression system we varied the amount and nature of th...
متن کاملA phase I study to evaluate a human papillomavirus (HPV) type 18 L1 VLP vaccine.
Human papillomavirus (HPV) infection can cause genital warts and cervical cancer. HPV types 6 and 11 cause >90% of genital wart cases; HPV16 and 18 cause 70% of cervical cancers. A prophylactic HPV (types 6, 11, 16, 18) L1 virus-like particle (VLP) vaccine may substantially reduce the incidence of these lesions. This report describes the results of a phase I study of the HPV18 component of such...
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ژورنال
عنوان ژورنال: Applied Biochemistry and Microbiology
سال: 2020
ISSN: 0003-6838,1608-3024
DOI: 10.1134/s0003683820010147